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What is a physical change associated with Cushing's syndrome?

  1. Bronze skin

  2. Truncal obesity

  3. Lordosis

  4. Exophthalmos

The correct answer is: Truncal obesity

Truncal obesity is a hallmark physical change commonly observed in individuals with Cushing's syndrome. This condition results from excessive cortisol levels, often due to endogenous overproduction or exogenous administration of corticosteroids. The redistribution of body fat is a defining characteristic of Cushing's syndrome, leading to an increase in fat around the abdomen and upper back, while fat loss may occur in the extremities. This specific pattern of fat distribution is crucial for recognizing the disorder. Other physical changes associated with Cushing's syndrome may include various skin changes, but truncal obesity distinctly captures the essence of the condition's impact on body composition and fat distribution. Recognizing this symptom aids in identifying potential patients who may need further testing for Cushing's syndrome.